EnglishTobey Maguire as Spider-Man/Peter Parker
Kirsten Dunst as Mary Jane Watson
James Franco as New Goblin/Harry Osborn
Thomas Haden Church as Sandman/Flint Marko
Topher Grace as Venom/Eddie Brock
Bryce Dallas Howard as Gwen Stacy
Rosemary Harris as May Parker
J K Simmons as J Jonah Jameson
James Cromwell as Captain Stacy
Theresa Russell as Emma Marko
Dylan Baker as Dr Curt Connors
Bill Nunn as Joseph 'Robbie' Robertson
Bruce Campbell as Maître d’
Elizabeth Banks as Miss Brant
Cliff Robertson as Uncle Ben Parker
Ted Raimi as Hoffman
Perla Haney-Jardine as Penny Marko
Elya Baskin as Mr Ditkovitch
Mageina Tovah as Ursula
John Paxton as Houseman
Becky Ann Baker as Mrs Stacy
Stan Lee as Man in Times Square
Michael Papajohn as Dennis Carradine/Carjacker
Joe Manganiello as Flash Thompson
Hal Fishman as Anchorman
Lucy Gordon as Jennifer Dugan
Steve Valentine as Photographer
Tim Maculan as Play Director
Marc Vann as Play Producer
Joe Bays as Jazz Club Manager
Gregg Daniel as Detective Neil Garrett
Rogelio T Ramos as Emergency room doctor
Timothy Patrick Quill as Crane Operator
Menachem Mendel Boymelgreen as Kid in Times Square
Nasir Stewart as Kid in Times Square
Austin Hendrickson as Kid in Times Square
Taylor Hemhauser as Kid in Times Square
Kathryn Bryding as Woman Outside Theater
Joe Virzi as Police Detective
Bill E Rogers as New Jersey State Policeman
Michael Alexander as New Jersey State Policeman
April Parker as Test Site Technician
Edward Padilla as Test Site Technician
Robert Curtis-Brown as Test Site Technician
Paul Terrell Clayton as Test Site Technician
Carolyn Neff as Test Site Technician
Christina Cindrich as Test Site Technician
Sonya Maddox as ICU Nurse
Andre B Blake as Crane Disaster Radio Policeman
Derrick 'Phoenix' Thomas as Cop at Crane Disaster
Jessi Collins as Mary Jane’s Replacement
Michael McLaughlin as Boy at Keys to the City Ceremony
Anne Gartland as Councilwoman
Emilio Rivera as Policeman at Sand Truck
Keith Woulard as Policeman at Sand Truck
Reynaldo Gallegos as Armored Car Driver
Jim Coope as Newsstand Patron
Dean Edwards as Newsstand Patron
Margaret Laney as Newsstand Patron
Toni Wynne as Congratulatory Woman at Daily Bugle
Aimee Miles as Coffee shop waitress
Tanya Sinovec as Jazz Club Waitress
Mark Kubr as Jazz Club Bouncer
Emma Raimi as Girl with Camera
Lorne Raimi as Boy at the Final Battle
Henry Raimi as Boy at the Final Battle
Samantha Ressler as Girl at the Final Battle
Alan Cohn as Jazz Club Musician
Dan Callahan as Jazz Club Musician
Ron King as Jazz Club Musician
Carol Chaikin as Jazz Club Musician
Dan Cummings as Jazz Club Musician
Vance Hammond as Jazz Club Musician
Maya Rosewood as Charlie's Mom
Abbey Skinner as Cafe Girl