EnglishChris Evans as Casey
Sarah Michelle Gellar as April O'Neil
Mako as Splinter
Kevin Smith as Diner Cook
Patrick Stewart as Winters
Ziyi Zhang as Karai
Laurence Fishburne as Narrator
Mitchell Whitfield as Donatello
James Arnold Taylor as Leonardo
Mikey Kelley as Michelangelo
Nolan North as Raphael/Nightwatcher
John Di Maggio as Colonel Santino
Paula Mattioli as General Serpiente
Kevin Michael Richardson as General Aguila/Additional Voices
Fred Tatasciore as General Gato
Dee Bradley Baker as Additional Voices
Greg Baldwin as Additional Voices
Jeff Bennett as Additional Voices
Jim Cummings as Additional Voices
Grey DeLisle as Additional Voices
Chris Edgerly as Additional Voices
Kim Mai Guest as Additional Voices
Jennifer Hale as Additional Voices
Jess Harnell as Additional Voices
Phil LaMarr as Additional Voices
Paul Michael Robinson as Additional Voices
Tara Strong as Additional Voices
Billy West as Additional Voices
Jason Broad as Background Voices (Wallah)
Willow Geer as Background Voices (Wallah)
Andy Hirsch as Background Voices (Wallah)
Barbara Iley as Background Voices (Wallah)
Terry Maratos as Background Voices (Wallah)
Jeremy Maxwell as Background Voices (Wallah)
Tracy Metro as Background Voices (Wallah)
David Michie as Background Voices (Wallah)
David Randolph as Background Voices (Wallah)
Vernon Scott as Background Voices (Wallah)
Andreana Weiner as Background Voices (Wallah)