NORMAN, Okla. (AP) -- Adrian Peterson weaved around the line, dodged a tackler and broke into the clear before diving across the goal line.

The Heisman hopeful's latest spectacular touchdown run might turn out to be his last in Norman.

Playing in a college game with his father in the stands for the first time, Peterson broke his collarbone at the end of the 53-yard gallop that finished off No. 23 Oklahoma's 34-9 victory over Iowa State on Saturday.

He is expected to miss the rest of the regular season, although he could return for a bowl game. The junior tailback is eligible to enter the NFL draft after this season and he'd likely be a first-round pick.

"He made a nice cut, made a great play. He made a bunch of great ones," Sooners offensive coordinator Kevin Wilson said. "Hopefully that won't be his last."

Peterson was injured with about 6:35 left in the game when he landed hard on his shoulder after falling into the end zone. He got right up and trotted off the field, but with his left arm dangling across the front of his body.

He finished with 183 yards rushing and two touchdowns playing for the first time in years before his father, Nelson Peterson, who had spent about eight years in federal prison for money laundering.

"Just diving into the end zone and when he landed, he landed wrong," Oklahoma coach Bob Stoops said. "At this point it looks like the best thing, the earliest he would be ready to play, would be a bowl game."

Peterson started strong with a 40-yard gain on his first carry to set up his 6-yard TD run two plays later.

Nelson Peterson watched it all from the stands just nine days after he was released from an Oklahoma City halfway house. He never saw his son play in high school or as he racked up an NCAA freshman record 1,925 rushing yards and finished second in the 2004 Heisman voting.

Oklahoma had planned to call both father and son into the interview room to discuss their big day. That was all canceled after X-rays revealed the injury.

"I'm pretty sure this will overshadow the kind of game he had," Oklahoma receiver Malcolm Kelly said. "I'm just imagining how I'm feeling right now but I can only imagine how he's feeling right now."

Peterson had said he expected his first game in front of his dad to be "exciting and emotional." But Stoops and Peterson's teammates said he didn't go out of his way to make it a special occasion.

"Nothing was really said about it. He didn't say anything about it before the game, but we were all aware of it," quarterback Paul Thompson said.

"It's kind of hard to tell when he's not fired up with how he runs but you could definitely tell that he wanted to have a big game, and he did."

Stoops said Peterson told him that the situation had been blown out of proportion and "TV is not a new invention, so he's been watching."

"Everybody said, `Well, now watch him.' That guy, he puts it all out there every time he goes," Stoops said. "I even mentioned that to him. I said, `You haven't been holding back on me? You don't have another gear, do you? He competes, he always has, with everything he's got."

In between Peterson's big runs, Thompson and Kelly hooked up for scores from 9 and 15 yards, the latter giving the Sooners (4-2, 1-1 Big 12) a 24-7 halftime lead. Thompson finished with 195 passing yards.

Iowa State got its only points of the second half on a safety after Peterson and Thompson botched a handoff in the end zone early in the second half. Peterson recovered the ball but then pitched it out of the back of the end zone as he was about to be tackled.

The Cyclones (3-4, 0-3) got only two first downs on their first six drives of the second half, and Bret Meyer's first interception -- on a diving catch by Rufus Alexander -- set up Garrett Hartley's 35-yard field goal in the third quarter.

Iowa State lost cornerback and kick returner DeAndre Jackson to a knee injury on a kickoff return in the second quarter.

"Unfortunately I think DeAndre Jackson has a torn ACL. I think his career is over," Cyclones coach Dan McCarney said. "We lost one of the great young men and one of the greatest players in the history of Iowa State football, and we will miss his leadership and his play."

Last season, Jackson tied for the team lead with five interceptions and finished second in the Big 12 with a 24.6-yard average on kick returns.

Meyer finished with 149 yards on 14-for-24 passing with two interceptions and a 31-yard touchdown pass to Todd Blythe that cut Oklahoma's lead to 14-7 late in the first quarter.