AMES, Iowa (AP) —Kyler Murray threw for 348 yards and three touchdowns and No. 5 Oklahoma held off Iowa State 37-27 on Saturday in the Big 12 opener for both teams.

Marquise Brown had 191 yards receiving and a TD for the Sooners (3-0, 1-0 Big 12), who extended the nation's longest road winning streak to 17 games while avenging a stunning home loss to the Cyclones a year ago.

Iowa State (0-2, 0-1) didn't make it easy for the Sooners, rallying from a 14-point halftime deficit to make it 34-27 late in the third quarter. But the Sooners killed nearly eight minutes on a drive that ended with a 42-yard field goal from Austin Siebert with 2:51 left, and Parnell Motley's interception with 1:11 to go sealed.

"Iowa State's a good team. You give them any room, they're going to capitalize on it. They're a tough out," Oklahoma coach Lincoln Riley said.

Backup Zeb Noland threw for a career-high 360 yards and a pair of long touchdown passes to Hakeem Butler for the Cyclones, who were without starting quarterback Kyle Kempt (knee).

Iowa State coach Matt Campbell said Kempt will also miss next week's game.

"I thought we settled in," Campbell said. "I thought we played much better in the second half than the first half."

THE TAKEAWAY
Oklahoma: Murray, who also ran for a team-high 77 yards, breezed through his first start on the road against a conference opponent -- and he and Brown looked like one of the most dangerous duos in the country. But the Sooners have to be a bit concerned about their defense, which had no answer for the 6-foot-6 Butler.

Iowa State: The Cyclones offense showed some life after a dismal showing last week in a 13-3 loss to Iowa. But what should be troubling for the rest of the Big 12 is that this was a pretty good defense that Murray and the Sooners carved up. Oklahoma gained 519 yards against the Cyclones, who allowed just 20.9 points a game in 2017.