Following a pilot film in August 2000, the cable network TNT premiered a Witchblade television series based on the Witchblade comic book series in 2001. The series was directed by Ralph Hemecker and written by Marc Silvestri (who also wrote the comic book) and J.D. Zeik.

Yancy Butler starred as Sara Pezzini, Anthony Cistaro as Kenneth Irons, David Chokachi as Jake McCartey, Eric Etebari as Ian Nottingham, Will Yun Lee as Danny Woo, Conrad Dunn as Gallo, Kenneth Walsh as Joe Siri, and John Hensley as Gabriel Bowman, among others. Although critically acclaimed and popular with audiences, it was cancelled in September 2002 after Butler was ordered to enter rehab for alcoholism.

The series ran for two seasons on TNT, each with 12 episodes. The first episode aired June 12, 2001; the last episode aired August 26, 2002. In spite of its cancellation, Witchblade was ranked seventh in the Top 10 Basic Cable Dramas for 2002 (Multichannel News, February 24, 2003).

On May 29th, 2007, the soundtrack for the series was released by composer Joel Goldsmith on his independent record label, FreeClyde.

A movie version is said to be released in 2007 and is in production.